3t4h: Difference between revisions

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-[[Image:3t4h.png|left|200px]]
-<!--
+==Crystal Structure of AlkB in complex with Fe(III) and N-Oxalyl-S-(3-nitrobenzyl)-L-cysteine==
-The line below this paragraph, containing "STRUCTURE_3t4h", creates the "Structure Box" on the page.
+<StructureSection load='3t4h' size='340' side='right'caption='[[3t4h]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3t4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T4H FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MD5:N-(CARBOXYCARBONYL)-S-(3-NITROBENZYL)-L-CYSTEINE'>MD5</scene></td></tr>
-{{STRUCTURE_3t4h|  PDB=3t4h  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t4h OCA], [https://pdbe.org/3t4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t4h RCSB], [https://www.ebi.ac.uk/pdbsum/3t4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t4h ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ALKB_ECOLI ALKB_ECOLI] Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents).<ref>PMID:12226668</ref> <ref>PMID:12594517</ref> <ref>PMID:16482161</ref> <ref>PMID:19706517</ref> <ref>PMID:21068844</ref> <ref>PMID:20084272</ref>
-===Crystal Structure of AlkB in complex with Fe(III) and N-Oxalyl-S-(3-nitrobenzyl)-L-cysteine===
+==See Also==
+*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_22263962}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 22263962 is the PubMed ID number.
+</StructureSection>
--->
+[[Category: Escherichia coli K-12]]
-{{ABSTRACT_PUBMED_22263962}}
+[[Category: Large Structures]]
+[[Category: Aik WS]]
-==About this Structure==
+[[Category: Ma J]]
-[[3t4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T4H OCA].
+[[Category: McDonough MA]]
+[[Category: Schofield CJ]]
-==Reference==
-<ref group="xtra">PMID:022263962</ref><references group="xtra"/>
-[[Category: Escherichia coli]]
-[[Category: Aik, W S.]]
-[[Category: Ma, J.]]
-[[Category: McDonough, M A.]]
-[[Category: Schofield, C J.]]
-[[Category: Double-stranded beta-helix]]
-[[Category: Nucleic acid demethylase]]
-[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]