3srq: Difference between revisions

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[[Image:3srq.jpg|left|200px]]


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==S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines==
The line below this paragraph, containing "STRUCTURE_3srq", creates the "Structure Box" on the page.
<StructureSection load='3srq' size='340' side='right'caption='[[3srq]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3srq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SRQ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=Q19:1-[3-(2,4-DIAMINO-6-METHYLQUINAZOLIN-7-YL)PHENYL]ETHANONE'>Q19</scene></td></tr>
{{STRUCTURE_3srq|  PDB=3srq  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3srq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3srq OCA], [https://pdbe.org/3srq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3srq RCSB], [https://www.ebi.ac.uk/pdbsum/3srq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3srq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.


===S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines===
==See Also==
 
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
 
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_21831637}}
 
==About this Structure==
[[3srq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SRQ OCA].
 
==Reference==
<ref group="xtra">PMID:021831637</ref><references group="xtra"/>
[[Category: Dihydrofolate reductase]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Hilgers, M.]]
[[Category: Hilgers M]]
[[Category: Dhfr]]
[[Category: Dihydrofolate reductase]]
[[Category: Drug design]]
[[Category: Enzyme inhibitor]]
[[Category: Folate]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Latest revision as of 12:56, 1 March 2024

S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolinesS. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines

Structural highlights

3srq is a 1 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.69Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DYR_STAAU Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

See Also

3srq, resolution 1.69Å

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