3shm: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3shm]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Adeno-associated_virus_-_6 Adeno-associated virus - 6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SHM FirstGlance]. <br>
<table><tr><td colspan='2'>[[3shm]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Adeno-associated_virus_-_6 Adeno-associated virus - 6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SHM FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3tsx|3tsx]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.019&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3shm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3shm OCA], [https://pdbe.org/3shm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3shm RCSB], [https://www.ebi.ac.uk/pdbsum/3shm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3shm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3shm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3shm OCA], [https://pdbe.org/3shm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3shm RCSB], [https://www.ebi.ac.uk/pdbsum/3shm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3shm ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/O56137_9VIRU O56137_9VIRU]
Crystal structures of the AAV-6 capsid at 3A reveal a subunit fold homologous to other parvoviruses with greatest differences in two external loops. The electrostatic potential suggests that receptor-attachment is mediated by four residues: Arg(576), Lys(493), Lys(459) and Lys(531), defining a positively charged region curving up from the valley between adjacent spikes. It overlaps only partially with the receptor-binding site of AAV-2, and the residues endowing the electrostatic character are not homologous. Mutational substitution of each residue decreases heparin affinity, particularly Lys(531) and Lys(459). Neither is conserved among heparin-binding serotypes, indicating that diverse modes of receptor attachment have been selected in different serotypes. Surface topology and charge are also distinct at the shoulder of the spike, where linear epitopes for AAV-2's neutralizing monoclonal antibody A20 come together. Evolutionarily, selection of changed side-chain charge may have offered a conservative means to evade immune neutralization while preserving other essential functionality.
 
Structure-function analysis of receptor-binding in adeno-associated virus serotype 6 (AAV-6).,Xie Q, Lerch TF, Meyer NL, Chapman MS Virology. 2011 Nov 10;420(1):10-9. Epub 2011 Sep 13. PMID:21917284<ref>PMID:21917284</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3shm" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Adeno-associated virus - 6]]
[[Category: Adeno-associated virus - 6]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chapman, M S]]
[[Category: Chapman MS]]
[[Category: Lerch, T F]]
[[Category: Lerch TF]]
[[Category: Meyer, N L]]
[[Category: Meyer NL]]
[[Category: Xie, Q]]
[[Category: Xie Q]]
[[Category: Beta barrel]]
[[Category: Virus]]

Latest revision as of 12:50, 1 March 2024

Structure-function Analysis of Receptor Binding in Adeno-Associated Virus Serotype 6 (AAV-6)Structure-function Analysis of Receptor Binding in Adeno-Associated Virus Serotype 6 (AAV-6)

Structural highlights

3shm is a 20 chain structure with sequence from Adeno-associated virus - 6. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.019Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

O56137_9VIRU

See Also

3shm, resolution 3.02Å

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OCA
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