3sgr: Difference between revisions

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[[Image:3sgr.jpg|left|200px]]


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==Tandem repeat of amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L==
The line below this paragraph, containing "STRUCTURE_3sgr", creates the "Structure Box" on the page.
<StructureSection load='3sgr' size='340' side='right'caption='[[3sgr]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3sgr]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SGR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
{{STRUCTURE_3sgr|  PDB=3sgr  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgr OCA], [https://pdbe.org/3sgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sgr RCSB], [https://www.ebi.ac.uk/pdbsum/3sgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sgr ProSAT]</span></td></tr>
 
</table>
===Tandem repeat of amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L===
== Disease ==
 
[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
 
== Function ==
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[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
The line below this paragraph, {{ABSTRACT_PUBMED_22403391}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 22403391 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_22403391}}
 
==About this Structure==
[[3sgr]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGR OCA].  
 
==Reference==
<ref group="xtra">PMID:022403391</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Cascio, D.]]
[[Category: Large Structures]]
[[Category: Eisenberg, D.]]
[[Category: Cascio D]]
[[Category: Laganowsky, A.]]
[[Category: Eisenberg D]]
[[Category: Sawaya, M R.]]
[[Category: Laganowsky A]]
[[Category: Amyloid]]
[[Category: Sawaya MR]]
[[Category: Amyloid oligomer]]
[[Category: Beta cylindrin]]
[[Category: Protein fibril]]

Latest revision as of 12:50, 1 March 2024

Tandem repeat of amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91LTandem repeat of amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L

Structural highlights

3sgr is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.17Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

CRYAB_HUMAN Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

CRYAB_HUMAN May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.

3sgr, resolution 2.17Å

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