3sba: Difference between revisions

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'''Unreleased structure'''


The entry 3sba is ON HOLD
==Zn-mediated Hexamer of T4 Lysozyme R76H/R80H by Synthetic Symmetrization==
<StructureSection load='3sba' size='340' side='right'caption='[[3sba]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3sba]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SBA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sba OCA], [https://pdbe.org/3sba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sba RCSB], [https://www.ebi.ac.uk/pdbsum/3sba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sba ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>


Authors: Soriaga, Angela B., Laganowsky, Arthur, Zhao, Minglei, Sawaya, Michael R., Cascio, Duilio, Yeates, Todd O., Eisenberg, David
==See Also==
 
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
Description: Zn-mediated Hexamer of T4 Lysozyme R76H/R80H by Synthetic Symmetrization
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia virus T4]]
[[Category: Large Structures]]
[[Category: Cascio D]]
[[Category: Laganowsky A]]
[[Category: Sawaya MR]]
[[Category: Soriaga AB]]
[[Category: Yeates TO]]
[[Category: Zhao M]]

Latest revision as of 12:49, 1 March 2024

Zn-mediated Hexamer of T4 Lysozyme R76H/R80H by Synthetic SymmetrizationZn-mediated Hexamer of T4 Lysozyme R76H/R80H by Synthetic Symmetrization

Structural highlights

3sba is a 6 chain structure with sequence from Escherichia virus T4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.75Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ENLYS_BPT4 Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.[1]

See Also

References

  1. Moussa SH, Kuznetsov V, Tran TA, Sacchettini JC, Young R. Protein determinants of phage T4 lysis inhibition. Protein Sci. 2012 Apr;21(4):571-82. doi: 10.1002/pro.2042. Epub 2012 Mar 2. PMID:22389108 doi:http://dx.doi.org/10.1002/pro.2042

3sba, resolution 2.75Å

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