3sb7: Difference between revisions

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[[Image:3sb7.png|left|200px]]


{{STRUCTURE_3sb7|  PDB=3sb7  |  SCENE=  }}
==Cu-mediated Trimer of T4 Lysozyme D61H/K65H/R76H/R80H by Synthetic Symmetrization==
 
<StructureSection load='3sb7' size='340' side='right'caption='[[3sb7]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
===Cu-mediated Trimer of T4 Lysozyme D61H/K65H/R76H/R80H by Synthetic Symmetrization===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3sb7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SB7 FirstGlance]. <br>
{{ABSTRACT_PUBMED_21898649}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sb7 OCA], [https://pdbe.org/3sb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sb7 RCSB], [https://www.ebi.ac.uk/pdbsum/3sb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sb7 ProSAT]</span></td></tr>
[[3sb7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SB7 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>


==See Also==
==See Also==
*[[Hen Egg-White (HEW) Lysozyme|Hen Egg-White (HEW) Lysozyme]]
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021898649</ref><references group="xtra"/>
__TOC__
[[Category: Enterobacteria phage t4]]
</StructureSection>
[[Category: Lysozyme]]
[[Category: Escherichia virus T4]]
[[Category: Cascio, D.]]
[[Category: Large Structures]]
[[Category: Laganowsky, A.]]
[[Category: Cascio D]]
[[Category: Sawaya, M R.]]
[[Category: Laganowsky A]]
[[Category: Soriaga, A B.]]
[[Category: Sawaya MR]]
[[Category: Yeates, T O.]]
[[Category: Soriaga AB]]
[[Category: Zhao, M.]]
[[Category: Yeates TO]]
[[Category: Hydrolase]]
[[Category: Zhao M]]
[[Category: Metal-mediated synthetic symmetrization]]
[[Category: Synthetic symmetrization]]

Latest revision as of 12:49, 1 March 2024

Cu-mediated Trimer of T4 Lysozyme D61H/K65H/R76H/R80H by Synthetic SymmetrizationCu-mediated Trimer of T4 Lysozyme D61H/K65H/R76H/R80H by Synthetic Symmetrization

Structural highlights

3sb7 is a 2 chain structure with sequence from Escherichia virus T4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ENLYS_BPT4 Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.[1]

See Also

References

  1. ↑ Moussa SH, Kuznetsov V, Tran TA, Sacchettini JC, Young R. Protein determinants of phage T4 lysis inhibition. Protein Sci. 2012 Apr;21(4):571-82. doi: 10.1002/pro.2042. Epub 2012 Mar 2. PMID:22389108 doi:http://dx.doi.org/10.1002/pro.2042

3sb7, resolution 2.70Å

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