3s7f: Difference between revisions

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-[[Image:3s7f.jpg|left|200px]]
-<!--
+==Structural Basis of Substrate Methylation and Inhibition of SMYD2==
-The line below this paragraph, containing "STRUCTURE_3s7f", creates the "Structure Box" on the page.
+<StructureSection load='3s7f' size='340' side='right'caption='[[3s7f]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3s7f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S7F FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_3s7f|  PDB=3s7f  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s7f OCA], [https://pdbe.org/3s7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s7f RCSB], [https://www.ebi.ac.uk/pdbsum/3s7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s7f ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>
-===Structural Basis of Substrate Methylation and Inhibition of SMYD2===
+==See Also==
+*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_21782458}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 21782458 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_21782458}}
-==About this Structure==
-[[3s7f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7F OCA].
-==Reference==
-<ref group="xtra">PMID:021782458</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Ferguson, A D.]]
+[[Category: Large Structures]]
-[[Category: Methyltransferase]]
+[[Category: Ferguson AD]]
-[[Category: Transferase]]