3roa: Difference between revisions

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[[Image:3roa.jpg|left|200px]]


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==Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(morpholin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1004)==
The line below this paragraph, containing "STRUCTURE_3roa", creates the "Structure Box" on the page.
<StructureSection load='3roa' size='340' side='right'caption='[[3roa]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3roa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ROA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ROA FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.301&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=06V:6-ETHYL-5-{(3R)-3-[3-METHOXY-5-(MORPHOLIN-4-YL)PHENYL]BUT-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>06V</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
{{STRUCTURE_3roa|  PDB=3roa  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3roa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3roa OCA], [https://pdbe.org/3roa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3roa RCSB], [https://www.ebi.ac.uk/pdbsum/3roa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3roa ProSAT]</span></td></tr>
 
</table>
===Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(morpholin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1004)===
== Function ==
 
[https://www.uniprot.org/uniprot/Q6FPH0_CANGA Q6FPH0_CANGA]  
 
__TOC__
==About this Structure==
</StructureSection>
[[3roa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ROA OCA].  
[[Category: Large Structures]]
[[Category: Candida glabrata]]
[[Category: Anderson AC]]
[[Category: Anderson, A C.]]
[[Category: Paulsen JL]]
[[Category: Paulsen, J L.]]
[[Category: Antifungal agent]]
[[Category: Candida glabrata]]
[[Category: Drug design]]
[[Category: Enzyme inhibitor]]
[[Category: Fungal protein]]
[[Category: Model]]
[[Category: Molecular structure]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Structure-activity relationship]]
[[Category: Tetrahydrofolate dehydrogenase]]

Latest revision as of 12:44, 1 March 2024

Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(morpholin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1004)Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(morpholin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1004)

Structural highlights

3roa is a 2 chain structure with sequence from Candida glabrata. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.301Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q6FPH0_CANGA

3roa, resolution 2.30Å

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OCA
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