5r4t: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5r4t is ON HOLD
+==PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with SK-430==
+<StructureSection load='5r4t' size='340' side='right'caption='[[5r4t]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
-Authors: Kidd, S.L., Mateu, N., Talon, R., Krojer, T., Aimon, A., Bradley, A.R., Fairhead, M., DÃÆÃÆÃâÃÂaz-SÃÆÃÆÃâÃÂ¡ez, L., Sore, H.F., Madin, A., Huber, K.V.M., von Delft, F., Spring, D.R.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5r4t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5R4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5R4T FirstGlance]. <br>
-Description: PanDDA analysis group deposition --Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with SK-430
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RWG:(5R)-5-{[1-(4-fluorophenyl)-1H-1,2,3-triazol-4-yl]methyl}-5-methylpyrrolidine-2,4-dione'>RWG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Spring, D.R]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5r4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5r4t OCA], [https://pdbe.org/5r4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5r4t RCSB], [https://www.ebi.ac.uk/pdbsum/5r4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5r4t ProSAT]</span></td></tr>
-[[Category: DãÆÃÆÃÂÃÂAz-SãÆÃÆÃÂÃÂ¡Ez, L]]
+</table>
-[[Category: Aimon, A]]
+== Function ==
-[[Category: Mateu, N]]
+[https://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN] Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:20479262</ref> <ref>PMID:21295486</ref>
-[[Category: Kidd, S.L]]
+== References ==
-[[Category: Madin, A]]
+<references/>
-[[Category: Fairhead, M]]
+__TOC__
-[[Category: Von Delft, F]]
+</StructureSection>
-[[Category: Bradley, A.R]]
+[[Category: Homo sapiens]]
-[[Category: Talon, R]]
+[[Category: Large Structures]]
-[[Category: Huber, K.V.M]]
+[[Category: Aimon A]]
-[[Category: Sore, H.F]]
+[[Category: Bradley AR]]
-[[Category: Krojer, T]]
+[[Category: Diaz-Saez L]]
+[[Category: Fairhead M]]
+[[Category: Huber KVM]]
+[[Category: Kidd SL]]
+[[Category: Krojer T]]
+[[Category: Madin A]]
+[[Category: Mateu N]]
+[[Category: Sore HF]]
+[[Category: Spring DR]]
+[[Category: Talon R]]
+[[Category: Von Delft F]]