5qt3: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5qt3 is ON HOLD
+==Ground state model of human erythroid-specific 5'-aminolevulinate synthase, ALAS2 - SGC Diamond Xchem fragment screening==
+<StructureSection load='5qt3' size='340' side='right'caption='[[5qt3]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-Authors: Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5qt3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QT3 FirstGlance]. <br>
-Description: Ground state model of human erythroid-specific 5'-aminolevulinate synthase, ALAS2 -SGC Diamond Xchem fragment screening
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-[[Category: Foster, W]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qt3 OCA], [https://pdbe.org/5qt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qt3 RCSB], [https://www.ebi.ac.uk/pdbsum/5qt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qt3 ProSAT]</span></td></tr>
-[[Category: Arrowsmith, C.H]]
+</table>
-[[Category: Brandao-Neto, J]]
+== Disease ==
-[[Category: Talon, R]]
+[https://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN] X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).<ref>PMID:21309041</ref>
-[[Category: Brennan, P.E]]
+== Function ==
-[[Category: Shrestha, L]]
+[https://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN]
-[[Category: Bezerra, G.A]]
+== References ==
-[[Category: Edwards, A]]
+<references/>
-[[Category: Nicola, B.B]]
+__TOC__
-[[Category: Douangamath, A]]
+</StructureSection>
-[[Category: Krojer, T]]
+[[Category: Homo sapiens]]
-[[Category: Yue, W.W]]
+[[Category: Large Structures]]
-[[Category: Von Delft, F]]
+[[Category: Arrowsmith CH]]
-[[Category: Bailey, H]]
+[[Category: Bailey H]]
-[[Category: Bountra, C]]
+[[Category: Bezerra GA]]
+[[Category: Bountra C]]
+[[Category: Brandao-Neto J]]
+[[Category: Brennan PE]]
+[[Category: Douangamath A]]
+[[Category: Edwards A]]
+[[Category: Foster W]]
+[[Category: Krojer T]]
+[[Category: Nicola BB]]
+[[Category: Shrestha L]]
+[[Category: Talon R]]
+[[Category: Yue WW]]
+[[Category: Von Delft F]]