5qrd: Difference between revisions
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New page: '''Unreleased structure''' The entry 5qrd is ON HOLD Authors: Bezerra, G.A., Foster, W., Shrestha L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, ... |
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==PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z1328968520== | |||
<StructureSection load='5qrd' size='340' side='right'caption='[[5qrd]], [[Resolution|resolution]] 1.76Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5qrd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QRD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QRD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=J4Q:4-[(2-methylsulfonylimidazol-1-yl)methyl]-1,3-thiazole'>J4Q</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | ||
[[Category: Foster | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qrd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qrd OCA], [https://pdbe.org/5qrd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qrd RCSB], [https://www.ebi.ac.uk/pdbsum/5qrd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qrd ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN] X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).<ref>PMID:21309041</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bailey H]] | |||
[[Category: Bezerra GA]] | |||
[[Category: Bountra C]] | |||
[[Category: Brandao-Neto J]] | |||
[[Category: Brennan PE]] | |||
[[Category: Douangamath A]] | |||
[[Category: Edwards A]] | |||
[[Category: Foster W]] | |||
[[Category: Krojer T]] | |||
[[Category: Nicola BB]] | |||
[[Category: Shrestha L]] | [[Category: Shrestha L]] | ||
[[Category: Talon R]] | |||
[[Category: Yue WW]] | |||
[[Category: Talon | [[Category: Von Delft F]] | ||
[[Category: Yue | |||
[[Category: Von Delft | |||
Latest revision as of 14:25, 21 February 2024
PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z1328968520PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z1328968520
Structural highlights
DiseaseHEM0_HUMAN X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).[1] FunctionReferences
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