3ozt: Difference between revisions

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-[[Image:3ozt.jpg|left|200px]]
-<!--
+==Rat catechol O-methyltransferase in complex with a catechol-type, 4-oxo-pyridinyl-containing inhibitor - humanized form==
-The line below this paragraph, containing "STRUCTURE_3ozt", creates the "Structure Box" on the page.
+<StructureSection load='3ozt' size='340' side='right'caption='[[3ozt]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ozt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OZT FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OZZ:N-[(E)-3-[(2R,3S,4R,5R)-3,4-DIHYDROXY-5-(4-OXOPYRIDIN-1-YL)OXOLAN-2-YL]PROP-2-ENYL]-2,3-DIHYDROXY-5-NITRO-BENZAMIDE'>OZZ</scene></td></tr>
-{{STRUCTURE_3ozt|  PDB=3ozt  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ozt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ozt OCA], [https://pdbe.org/3ozt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ozt RCSB], [https://www.ebi.ac.uk/pdbsum/3ozt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ozt ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
-===Rat catechol O-Methyltransferase in complex with a bisubstrate inhibitor - humanized form===
+==See Also==
+*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[3ozt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OZT OCA].
+[[Category: Large Structures]]
-[[Category: Catechol O-methyltransferase]]
 [[Category: Rattus norvegicus]]
-[[Category: Rudolph, M G.]]
+[[Category: Benz J]]
+[[Category: Ehler A]]
+[[Category: Rudolph MG]]
+[[Category: Schlatter D]]
+[[Category: Stihle M]]