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| ==Crystal structure of TTHA0988 in space group P6522== | | ==Crystal structure of TTHA0988 in space group P6522== |
| <StructureSection load='3ore' size='340' side='right' caption='[[3ore]], [[Resolution|resolution]] 2.90Å' scene=''> | | <StructureSection load='3ore' size='340' side='right'caption='[[3ore]], [[Resolution|resolution]] 2.90Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[3ore]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ORE FirstGlance]. <br> | | <table><tr><td colspan='2'>[[3ore]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ORE FirstGlance]. <br> |
| </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3oep|3oep]], [[3opf|3opf]]</td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> |
| <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ttha0988 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ore FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ore OCA], [https://pdbe.org/3ore PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ore RCSB], [https://www.ebi.ac.uk/pdbsum/3ore PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ore ProSAT]</span></td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ore FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ore OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ore RCSB], [http://www.ebi.ac.uk/pdbsum/3ore PDBsum]</span></td></tr> | |
| </table> | | </table> |
| <div style="background-color:#fffaf0;">
| | == Function == |
| == Publication Abstract from PubMed == | | [https://www.uniprot.org/uniprot/Q5SJM0_THET8 Q5SJM0_THET8] |
| The Thermus thermophilus protein TTHA0988 is a protein of unknown function which represents a fusion of two proteins found almost ubiquitously across the bacterial kingdom. These two proteins perform a role regulating sporulation in Bacillus subtilis, where they are known as KipI and KipA. kipI and kipA genes are usually found immediately adjacent to each other and are often fused to produce a single polypeptide, as is the case with TTHA0988. Here, three crystal forms are reported of TTHA0988, the first structure to be solved from the family of `KipI-KipA fusion' proteins. Comparison of the three forms reveals structural flexibility which can be described as a hinge motion between the `KipI' and `KipA' components. TTHA0988 is annotated in various databases as a putative allophanate hydrolase. However, no such activity could be identified and genetic analysis across species with known allophanate hydrolases indicates that a misannotation has occurred.
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| The structure of TTHA0988 from Thermus thermophilus, a KipI-KipA homologue incorrectly annotated as an allophanate hydrolase.,Jacques DA, Langley DB, Kuramitsu S, Yokoyama S, Trewhella J, Guss JM Acta Crystallogr D Biol Crystallogr. 2011 Feb;67(Pt 2):105-11. Epub 2011, Jan 8. PMID:21245531<ref>PMID:21245531</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| [[Category: Thermus thermophilus]] | | [[Category: Large Structures]] |
| [[Category: Guss, J M]] | | [[Category: Thermus thermophilus HB8]] |
| [[Category: Jacques, D A]] | | [[Category: Guss JM]] |
| [[Category: Kuramitsu, S]] | | [[Category: Jacques DA]] |
| [[Category: Structural genomic]] | | [[Category: Kuramitsu S]] |
| [[Category: Trewhella, J]] | | [[Category: Trewhella J]] |
| [[Category: Yokoyama, S]] | | [[Category: Yokoyama S]] |
| [[Category: Allophanate hydrolase]]
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| [[Category: Cyclophilin]]
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| [[Category: Kipa]]
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| [[Category: Kipi]]
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| [[Category: National project on protein structural and functional analyse]]
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| [[Category: Nppsfa]]
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| [[Category: Rsgi]]
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| [[Category: Unknown function]]
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