3olr: Difference between revisions

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-[[Image:3olr.png|left|200px]]
-{{STRUCTURE_3olr|  PDB=3olr  |  SCENE=  }}
+==PTPN22 in complex with consensus phospho-tyrosine peptide 1==
+<StructureSection load='3olr' size='340' side='right'caption='[[3olr]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-===PTPN22 in complex with consensus phospho-tyrosine peptide 1===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3olr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OLR FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-[[3olr]] is a 8 chain structure of [[Proten tyrosine phosphatase]] and [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OLR OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3olr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3olr OCA], [https://pdbe.org/3olr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3olr RCSB], [https://www.ebi.ac.uk/pdbsum/3olr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3olr ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN] Defects in PTPN22 are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:[https://omim.org/entry/152700 152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:15273934</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN] Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.<ref>PMID:16461343</ref> <ref>PMID:18056643</ref> <ref>PMID:19167335</ref> <ref>PMID:21719704</ref>
 ==See Also==
-*[[Proten tyrosine phosphatase|Proten tyrosine phosphatase]]
+*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
-*[[Tyrosine phosphatase|Tyrosine phosphatase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Protein-tyrosine-phosphatase]]
+[[Category: Large Structures]]
-[[Category: Sun, J P.]]
+[[Category: Sun J-P]]
-[[Category: Yu, X.]]
+[[Category: Yu X]]
-[[Category: Zhang, S.]]
+[[Category: Zhang S]]
-[[Category: Zhang, Z Y.]]
+[[Category: Zhang Z-Y]]
-[[Category: Hydrolase]]
-[[Category: Lyp]]
-[[Category: Phosphatase]]
-[[Category: Ptpn22]]