3oe4: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 3oe4 is ON HOLD
+==Rat catechol O-methyltransferase in complex with a catechol-type, purine-containing bisubstrate inhibitor - humanized form==
+<StructureSection load='3oe4' size='340' side='right'caption='[[3oe4]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3oe4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OE4 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=610:N-[(E)-3-[(2R,3S,4R,5R)-3,4-DIHYDROXY-5-PURIN-9-YL-OXOLAN-2-YL]PROP-2-ENYL]-2,3-DIHYDROXY-5-NITRO-BENZAMIDE'>610</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oe4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oe4 OCA], [https://pdbe.org/3oe4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oe4 RCSB], [https://www.ebi.ac.uk/pdbsum/3oe4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oe4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
-Authors: Rudolph, M.G.
+==See Also==
+*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
-Description: RAT CATECHOL O-METHYLTRANSFERASE IN COMPLEX WITH A BISUBSTRATE INHIBITOR -HUMANIZED FORM
+__TOC__
+</StructureSection>
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:38:35 2010''
+[[Category: Large Structures]]
+[[Category: Rattus norvegicus]]
+[[Category: Benz J]]
+[[Category: Ehler A]]
+[[Category: Rudolph MG]]
+[[Category: Schlatter D]]
+[[Category: Stihle M]]