3qrr: Difference between revisions

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[[Image:3qrr.png|left|200px]]


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==Structure of Thermus Thermophilus Cse3 bound to an RNA representing a product complex==
The line below this paragraph, containing "STRUCTURE_3qrr", creates the "Structure Box" on the page.
<StructureSection load='3qrr' size='340' side='right'caption='[[3qrr]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3qrr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QRR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.099&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=23G:GUANOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>23G</scene></td></tr>
{{STRUCTURE_3qrr|  PDB=3qrr  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrr OCA], [https://pdbe.org/3qrr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qrr RCSB], [https://www.ebi.ac.uk/pdbsum/3qrr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qrr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAS6_THET8 CAS6_THET8] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This enzyme processes pre-crRNA into individual crRNA units, but may not actually undergo enzyme turnover, retaining the crRNA product (PubMed:21572442). Generates a 2',3'-cyclic phosphodiester.<ref>PMID:21572442</ref> <ref>PMID:21572444</ref>  


===Structure of Thermus Thermophilus Cse3 bound to an RNA representing a product complex===
==See Also==
 
*[[CRISPR type I-E (Cascade)|CRISPR type I-E (Cascade)]]
 
== References ==
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_21572444}}
[[Category: Thermus thermophilus HB8]]
 
[[Category: Garside EL]]
==About this Structure==
[[Category: Gesner EG]]
[[3qrr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRR OCA].
[[Category: MacMillan AM]]
 
[[Category: Schellenberg MJ]]
==Reference==
<ref group="xtra">PMID:021572444</ref><references group="xtra"/>
[[Category: Thermus thermophilus hb8]]
[[Category: E L., Garside.]]
[[Category: Gesner, E G.]]
[[Category: MacMillan, A M.]]
[[Category: Schellenberg, M J.]]
[[Category: Protein-rna complex]]
[[Category: Ramp domain]]
[[Category: Rna binding protein-rna complex]]

Latest revision as of 13:49, 21 February 2024

Structure of Thermus Thermophilus Cse3 bound to an RNA representing a product complexStructure of Thermus Thermophilus Cse3 bound to an RNA representing a product complex

Structural highlights

3qrr is a 2 chain structure with sequence from Thermus thermophilus HB8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.099Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CAS6_THET8 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This enzyme processes pre-crRNA into individual crRNA units, but may not actually undergo enzyme turnover, retaining the crRNA product (PubMed:21572442). Generates a 2',3'-cyclic phosphodiester.[1] [2]

See Also

References

  1. ↑ Sashital DG, Jinek M, Doudna JA. An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3. Nat Struct Mol Biol. 2011 Jun;18(6):680-7. Epub 2011 May 15. PMID:21572442 doi:10.1038/nsmb.2043
  2. ↑ Gesner EM, Schellenberg MJ, Garside EL, George MM, Macmillan AM. Recognition and maturation of effector RNAs in a CRISPR interference pathway. Nat Struct Mol Biol. 2011 May 15. PMID:21572444 doi:10.1038/nsmb.2042

3qrr, resolution 3.10Å

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