3qi4: Difference between revisions

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'''Unreleased structure'''


The entry 3qi4 is ON HOLD
==Crystal structure of PDE9A(Q453E) in complex with IBMX==
<StructureSection load='3qi4' size='340' side='right'caption='[[3qi4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3qi4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QI4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IBM:3-ISOBUTYL-1-METHYLXANTHINE'>IBM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qi4 OCA], [https://pdbe.org/3qi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qi4 RCSB], [https://www.ebi.ac.uk/pdbsum/3qi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qi4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>


Authors: Hou, J., Xu, J., Liu, M., Zhao, R., Lou, H., Ke, H.
==See Also==
 
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
Description: Crystal structure of PDE9A(Q453E) in complex with IBMX
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hou J]]
[[Category: Ke H]]
[[Category: Liu M]]
[[Category: Lou H]]
[[Category: Xu J]]
[[Category: Zhao R]]

Latest revision as of 13:48, 21 February 2024

Crystal structure of PDE9A(Q453E) in complex with IBMXCrystal structure of PDE9A(Q453E) in complex with IBMX

Structural highlights

3qi4 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PDE9A_HUMAN Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.[1]

See Also

References

  1. ↑ Liu S, Mansour MN, Dillman KS, Perez JR, Danley DE, Aeed PA, Simons SP, Lemotte PK, Menniti FS. Structural basis for the catalytic mechanism of human phosphodiesterase 9. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13309-14. Epub 2008 Aug 29. PMID:18757755

3qi4, resolution 2.50Å

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