3ptg: Difference between revisions

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-[[Image:3ptg.png|left|200px]]
-<!--
+==Design and Synthesis of a Novel, Orally Efficacious Tri-substituted Thiophene Based JNK Inhibitor==
-The line below this paragraph, containing "STRUCTURE_3ptg", creates the "Structure Box" on the page.
+<StructureSection load='3ptg' size='340' side='right'caption='[[3ptg]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ptg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PTG FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=932:N-[4-METHYL-3-(1H-1,2,4-TRIAZOL-5-YL)THIOPHEN-2-YL]-2-(2-OXO-3,4-DIHYDROQUINOLIN-1(2H)-YL)ACETAMIDE'>932</scene></td></tr>
-{{STRUCTURE_3ptg|  PDB=3ptg  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ptg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ptg OCA], [https://pdbe.org/3ptg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ptg RCSB], [https://www.ebi.ac.uk/pdbsum/3ptg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ptg ProSAT]</span></td></tr>
+</table>
-===Design and Synthesis of a Novel, Orally Efficacious Tri-substituted Thiophene Based JNK Inhibitor===
+== Disease ==
+[https://www.uniprot.org/uniprot/JIP1_HUMAN JIP1_HUMAN] Defects in MAPK8IP1 are a cause of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:[https://omim.org/entry/125853 125853]. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.<ref>PMID:10700186</ref>
+== Function ==
-<!--
+[https://www.uniprot.org/uniprot/JIP1_HUMAN JIP1_HUMAN] The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.
-The line below this paragraph, {{ABSTRACT_PUBMED_21316234}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 21316234 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_21316234}}
-==About this Structure==
-[[3ptg]] is a 2 chain structure of [[Mitogen-activated protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PTG OCA].
 ==See Also==
-*[[Mitogen-activated protein kinase]]
+*[[Mitogen-activated protein kinase 3D structures|Mitogen-activated protein kinase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:21316234</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Mitogen-activated protein kinase]]
+[[Category: Large Structures]]
-[[Category: Artis, D R.]]
+[[Category: Artis DR]]
-[[Category: Bard, F.]]
+[[Category: Bard F]]
-[[Category: Bowers, S.]]
+[[Category: Bowers S]]
-[[Category: Brigham, E F.]]
+[[Category: Brigham EF]]
-[[Category: Griswold-Prenner, I.]]
+[[Category: Griswold-Prenner I]]
-[[Category: Hom, R K.]]
+[[Category: Hom RK]]
-[[Category: Konradi, A W.]]
+[[Category: Konradi AW]]
-[[Category: Neitz, J.]]
+[[Category: Neitz J]]
-[[Category: Neitzel, M.]]
+[[Category: Neitzel M]]
-[[Category: Pan, H.]]
+[[Category: Pan H]]
-[[Category: Powell, K.]]
+[[Category: Powell K]]
-[[Category: Probst, G D.]]
+[[Category: Probst GD]]
-[[Category: Quinn, K P.]]
+[[Category: Quinn KP]]
-[[Category: Ruslim, L.]]
+[[Category: Ruslim L]]
-[[Category: Sauer, J.]]
+[[Category: Sauer J]]
-[[Category: Sham, H L.]]
+[[Category: Sham HL]]
-[[Category: Toth, G.]]
+[[Category: Toth G]]
-[[Category: Truong, A P.]]
+[[Category: Truong AP]]
-[[Category: Yao, N.]]
+[[Category: Yao N]]
-[[Category: Yednock, T A.]]
+[[Category: Yednock TA]]