3pta: Difference between revisions

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-[[Image:3pta.jpg|left|200px]]
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+==Crystal structure of human DNMT1(646-1600) in complex with DNA==
-The line below this paragraph, containing "STRUCTURE_3pta", creates the "Structure Box" on the page.
+<StructureSection load='3pta' size='340' side='right'caption='[[3pta]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3pta]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PTA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PTA FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_3pta|  PDB=3pta  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pta OCA], [https://pdbe.org/3pta PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pta RCSB], [https://www.ebi.ac.uk/pdbsum/3pta PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pta ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/DNMT1_HUMAN DNMT1_HUMAN] Defects in DNMT1 are the cause of hereditary sensory neuropathy type 1E (HSN1E) [MIM:[https://omim.org/entry/614116 614116]. A neurodegenerative disorder characterized by adult onset of progressive peripheral sensory loss associated with progressive hearing impairment and early-onset dementia.<ref>PMID:21532572</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/DNMT1_HUMAN DNMT1_HUMAN] Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.<ref>PMID:16357870</ref> <ref>PMID:18754681</ref> <ref>PMID:18413740</ref>
-===Crystal structure of human DNMT1(646-1600) in complex with DNA===
+==See Also==
+*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_21163962}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 21163962 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_21163962}}
-==About this Structure==
-[[3pta]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PTA OCA].
-==Reference==
-<ref group="xtra">PMID:21163962</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Patel, D J.]]
+[[Category: Large Structures]]
-[[Category: Song, J.]]
+[[Category: Patel DJ]]
-[[Category: Dnmt1]]
+[[Category: Song J]]
-[[Category: Maintenance dna methylation]]
-[[Category: Transferase-dna complex]]