3onm: Difference between revisions

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<StructureSection load='3onm' size='340' side='right'caption='[[3onm]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3onm' size='340' side='right'caption='[[3onm]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3onm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Yerp3 Yerp3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ONM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ONM FirstGlance]. <br>
<table><tr><td colspan='2'>[[3onm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pseudotuberculosis_IP_31758 Yersinia pseudotuberculosis IP 31758]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ONM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ONM FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lrhA, RovM, YpsIP31758_1452 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=349747 YERP3])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3onm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3onm OCA], [https://pdbe.org/3onm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3onm RCSB], [https://www.ebi.ac.uk/pdbsum/3onm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3onm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3onm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3onm OCA], [https://pdbe.org/3onm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3onm RCSB], [https://www.ebi.ac.uk/pdbsum/3onm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3onm ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
In enteropathogenic Yersinia, the expression of several early-phase virulence factors such as invasin is tightly regulated in response to environmental cues. The responsible regulatory network is complex, involving several regulatory RNAs and proteins such as the LysR-type transcription regulator (LTTR) RovM. In this study, the crystal structure of the effector-binding domain (EBD) of RovM, the first LTTR protein described as being involved in virulence regulation, was determined at a resolution of 2.4 A. Size-exclusion chromatography and comparison with structures of full-length LTTRs show that RovM is most likely to adopt a tetrameric arrangement with two distant DNA-binding domains (DBDs), causing the DNA to bend around it. Additionally, a cavity was detected in RovM which could bind small inducer molecules.
Structure of the effector-binding domain of the LysR-type transcription factor RovM from Yersinia pseudotuberculosis.,Quade N, Dieckmann M, Haffke M, Heroven AK, Dersch P, Heinz DW Acta Crystallogr D Biol Crystallogr. 2011 Feb;67(Pt 2):81-90. Epub 2011, Jan 8. PMID:21245528<ref>PMID:21245528</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3onm" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Yerp3]]
[[Category: Yersinia pseudotuberculosis IP 31758]]
[[Category: Dersch, P]]
[[Category: Dersch P]]
[[Category: Diekmann, M]]
[[Category: Diekmann M]]
[[Category: Haffke, M]]
[[Category: Haffke M]]
[[Category: Heinz, D W]]
[[Category: Heinz DW]]
[[Category: Heroven, A K]]
[[Category: Heroven AK]]
[[Category: Quade, N]]
[[Category: Quade N]]
[[Category: Lysr]]
[[Category: Rovm]]
[[Category: Transcription]]
[[Category: Transcription factor]]
[[Category: Virulence factor]]

Latest revision as of 13:35, 21 February 2024

Effector binding Domain of LysR-Type transcription factor RovM from Y. pseudotuberculosisEffector binding Domain of LysR-Type transcription factor RovM from Y. pseudotuberculosis

Structural highlights

3onm is a 2 chain structure with sequence from Yersinia pseudotuberculosis IP 31758. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

3onm, resolution 2.40Å

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