3ols: Difference between revisions

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-[[Image:3ols.png|left|200px]]
-{{STRUCTURE_3ols|  PDB=3ols  |  SCENE=  }}
+==Crystal structure of estrogen receptor beta ligand binding domain==
+<StructureSection load='3ols' size='340' side='right'caption='[[3ols]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-===Crystal structure of estrogen receptor beta ligand binding domain===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3ols]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OLS FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EST:ESTRADIOL'>EST</scene></td></tr>
-[[3ols]] is a 4 chain structure of [[Estrogen receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OLS OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ols FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ols OCA], [https://pdbe.org/3ols PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ols RCSB], [https://www.ebi.ac.uk/pdbsum/3ols PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ols ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
 ==See Also==
-*[[Estrogen receptor|Estrogen receptor]]
+*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:020922740</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Brunsveld, L.]]
+[[Category: Large Structures]]
-[[Category: Carraz, M.]]
+[[Category: Brunsveld L]]
-[[Category: Moecklinghoff, S.]]
+[[Category: Carraz M]]
-[[Category: Ottmann, C.]]
+[[Category: Moecklinghoff S]]
-[[Category: Rose, R.]]
+[[Category: Ottmann C]]
-[[Category: Visser, A.]]
+[[Category: Rose R]]
-[[Category: Hormone receptor-activator complex]]
+[[Category: Visser A]]
-[[Category: Steroid binding]]