3nj0: Difference between revisions

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[[Image:3nj0.png|left|200px]]


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==X-ray crystal structure of the PYL2-pyrabactin A complex==
The line below this paragraph, containing "STRUCTURE_3nj0", creates the "Structure Box" on the page.
<StructureSection load='3nj0' size='340' side='right'caption='[[3nj0]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3nj0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NJ0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PYV:4-BROMO-N-(PYRIDIN-2-YLMETHYL)NAPHTHALENE-1-SULFONAMIDE'>PYV</scene></td></tr>
{{STRUCTURE_3nj0| PDB=3nj0 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nj0 OCA], [https://pdbe.org/3nj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nj0 RCSB], [https://www.ebi.ac.uk/pdbsum/3nj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nj0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nj/3nj0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nj0 ConSurf].
<div style="clear:both"></div>


===X-ray crystal structure of the PYL2-pyrabactin A complex===
==See Also==
 
*[[Abscisic acid receptor 3D structures|Abscisic acid receptor 3D structures]]
 
== References ==
<!--
<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 20729860 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20729860}}
 
==About this Structure==
[[3nj0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NJ0 OCA].
 
==Reference==
<ref group="xtra">PMID:20729860</ref><references group="xtra"/>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Bingman, C A.]]
[[Category: Large Structures]]
[[Category: Burgie, E S.]]
[[Category: Bingman CA]]
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
[[Category: Burgie ES]]
[[Category: Cutler, S R.]]
[[Category: Cutler SR]]
[[Category: Jensen, D R.]]
[[Category: Jensen DR]]
[[Category: Peterson, F C.]]
[[Category: Peterson FC]]
[[Category: Phillips, G N.]]
[[Category: Phillips Jr GN]]
[[Category: Volkman, B F.]]
[[Category: Volkman BF]]

Latest revision as of 13:30, 21 February 2024

X-ray crystal structure of the PYL2-pyrabactin A complexX-ray crystal structure of the PYL2-pyrabactin A complex

Structural highlights

3nj0 is a 3 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.89Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PYL2_ARATH Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Li J, Peterson FC, Jensen DR, Yong EL, Volkman BF, Cutler SR, Zhu JK, Xu HE. A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature. 2009 Dec 3;462(7273):602-8. PMID:19898420 doi:10.1038/nature08613
  2. ↑ Yin P, Fan H, Hao Q, Yuan X, Wu D, Pang Y, Yan C, Li W, Wang J, Yan N. Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol. 2009 Dec;16(12):1230-6. Epub 2009 Nov 5. PMID:19893533 doi:10.1038/nsmb.1730

3nj0, resolution 1.89Å

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