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==Crystal Structure of PFC0360w, an HSP90 activator from plasmodium falciparum== | ==Crystal Structure of PFC0360w, an HSP90 activator from plasmodium falciparum== | ||
<StructureSection load='3ni8' size='340' side='right' caption='[[3ni8]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='3ni8' size='340' side='right'caption='[[3ni8]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ni8]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3ni8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NI8 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ni8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ni8 OCA], [https://pdbe.org/3ni8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ni8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ni8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ni8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q689C4_PLAFA Q689C4_PLAFA] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ni/3ni8_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ni/3ni8_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ni8 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Plasmodium falciparum]] | [[Category: Plasmodium falciparum]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Bochkarev | [[Category: Bochkarev A]] | ||
[[Category: Bountra | [[Category: Bountra C]] | ||
[[Category: Cossar | [[Category: Cossar D]] | ||
[[Category: Edwards | [[Category: Edwards AM]] | ||
[[Category: Hills | [[Category: Hills T]] | ||
[[Category: Hui | [[Category: Hui R]] | ||
[[Category: Hutchinson | [[Category: Hutchinson A]] | ||
[[Category: Kozieradzki | [[Category: Kozieradzki I]] | ||
[[Category: MacKenzie | [[Category: MacKenzie F]] | ||
[[Category: Pizzaro | [[Category: Pizzaro JC]] | ||
[[Category: Sullivan H]] | |||
[[Category: Sullivan | [[Category: Weigelt J]] | ||
[[Category: Weigelt | [[Category: Wernimont AK]] | ||
[[Category: Wernimont | |||
Latest revision as of 13:30, 21 February 2024
Crystal Structure of PFC0360w, an HSP90 activator from plasmodium falciparumCrystal Structure of PFC0360w, an HSP90 activator from plasmodium falciparum
Structural highlights
FunctionEvolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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