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[[Image:3na0.png|left|200px]]


{{STRUCTURE_3na0|  PDB=3na0  |  SCENE=  }}
==Crystal structure of human CYP11A1 in complex with 20,22-dihydroxycholesterol==
 
<StructureSection load='3na0' size='340' side='right'caption='[[3na0]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===Crystal structure of human CYP11A1 in complex with 20,22-dihydroxycholesterol===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3na0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NA0 FirstGlance]. <br>
{{ABSTRACT_PUBMED_21636783}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2DC:(3ALPHA,8ALPHA,22R)-CHOLEST-5-ENE-3,20,22-TRIOL'>2DC</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3na0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3na0 OCA], [https://pdbe.org/3na0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3na0 RCSB], [https://www.ebi.ac.uk/pdbsum/3na0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3na0 ProSAT]</span></td></tr>
[[3na0]] is a 4 chain structure of [[Ferredoxin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NA0 OCA].  
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CP11A_HUMAN CP11A_HUMAN] Inherited isolated adrenal insufficiency due to CYP11A1 deficiency;46,XY disorder of sex development - adrenal insufficiency due to CYP11A1 deficiency. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/CP11A_HUMAN CP11A_HUMAN] Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.<ref>PMID:21636783</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/na/3na0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3na0 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Ferredoxin|Ferredoxin]]
*[[Ferredoxin 3D structures|Ferredoxin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021636783</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Botchkarev, A.]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C.]]
[[Category: Botchkarev A]]
[[Category: Edwards, A M.]]
[[Category: Bountra C]]
[[Category: MacKenzie, F.]]
[[Category: Edwards AM]]
[[Category: Park, H.]]
[[Category: MacKenzie F]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Park H]]
[[Category: Strushkevich, N V.]]
[[Category: Strushkevich NV]]
[[Category: Tempel, W.]]
[[Category: Tempel W]]
[[Category: Weigelt, J U.]]
[[Category: Weigelt JU]]
[[Category: 20]]
[[Category: 22-dihydroxycholesterol]]
[[Category: Cytochrome p450]]
[[Category: Electron transport]]
[[Category: Oxidoreductase]]
[[Category: Sgc]]
[[Category: Side chain cleavage]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]

Latest revision as of 13:28, 21 February 2024

Crystal structure of human CYP11A1 in complex with 20,22-dihydroxycholesterolCrystal structure of human CYP11A1 in complex with 20,22-dihydroxycholesterol

Structural highlights

3na0 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

CP11A_HUMAN Inherited isolated adrenal insufficiency due to CYP11A1 deficiency;46,XY disorder of sex development - adrenal insufficiency due to CYP11A1 deficiency. The disease is caused by mutations affecting the gene represented in this entry.

Function

CP11A_HUMAN Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Strushkevich N, Mackenzie F, Cherkesova T, Grabovec I, Usanov S, Park HW. Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system. Proc Natl Acad Sci U S A. 2011 Jun 2. PMID:21636783 doi:10.1073/pnas.1019441108

3na0, resolution 2.50Å

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