3na0: Difference between revisions

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-'''Unreleased structure'''
-The entry 3na0 is ON HOLD  until Aug 06 2011
+==Crystal structure of human CYP11A1 in complex with 20,22-dihydroxycholesterol==
+<StructureSection load='3na0' size='340' side='right'caption='[[3na0]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3na0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NA0 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2DC:(3ALPHA,8ALPHA,22R)-CHOLEST-5-ENE-3,20,22-TRIOL'>2DC</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3na0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3na0 OCA], [https://pdbe.org/3na0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3na0 RCSB], [https://www.ebi.ac.uk/pdbsum/3na0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3na0 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CP11A_HUMAN CP11A_HUMAN] Inherited isolated adrenal insufficiency due to CYP11A1 deficiency;46,XY disorder of sex development - adrenal insufficiency due to CYP11A1 deficiency. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/CP11A_HUMAN CP11A_HUMAN] Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.<ref>PMID:21636783</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/na/3na0_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3na0 ConSurf].
+<div style="clear:both"></div>
-Authors: Strushkevich, N.V., MacKenzie, F., Tempel, W., Botchkarev, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J.U., Park, H., Structural Genomics Consortium (SGC)
+==See Also==
+*[[Ferredoxin 3D structures|Ferredoxin 3D structures]]
-Description: Crystal structure of human CYP11A1 in complex with 20,22-dihydroxycholesterol
+== References ==
+<references/>
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug  4 08:47:31 2010''
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Arrowsmith CH]]
+[[Category: Botchkarev A]]
+[[Category: Bountra C]]
+[[Category: Edwards AM]]
+[[Category: MacKenzie F]]
+[[Category: Park H]]
+[[Category: Strushkevich NV]]
+[[Category: Tempel W]]
+[[Category: Weigelt JU]]