3n45: Difference between revisions

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[[Image:3n45.png|left|200px]]


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==Human FPPS complex with FBS_04 and zoledronic acid/MG2+==
The line below this paragraph, containing "STRUCTURE_3n45", creates the "Structure Box" on the page.
<StructureSection load='3n45' size='340' side='right'caption='[[3n45]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3n45]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N45 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3N3:(2S)-1-[(BENZYLOXY)CARBONYL]-2,3-DIHYDRO-1H-INDOLE-2-CARBOXYLIC+ACID'>3N3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZOL:ZOLEDRONIC+ACID'>ZOL</scene></td></tr>
{{STRUCTURE_3n45| PDB=3n45 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n45 OCA], [https://pdbe.org/3n45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n45 RCSB], [https://www.ebi.ac.uk/pdbsum/3n45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n45 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/3n45_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n45 ConSurf].
<div style="clear:both"></div>


===Human FPPS complex with FBS_04 and zoledronic acid/MG2+===
==See Also==
 
*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
 
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{{ABSTRACT_PUBMED_20711197}}
 
==About this Structure==
3N45 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N45 OCA].
 
==Reference==
<ref group="xtra">PMID:20711197</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Rondeau, J M.]]
[[Category: Large Structures]]
[[Category: Bisphosphonate]]
[[Category: Rondeau J-M]]
[[Category: Cholesterol biosynthesis]]
[[Category: Fragment-based screening]]
[[Category: Isoprene biosynthesis]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibiator complex]]
[[Category: Transferase-transferase inhibitor complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep  1 09:26:31 2010''

Latest revision as of 13:27, 21 February 2024

Human FPPS complex with FBS_04 and zoledronic acid/MG2+Human FPPS complex with FBS_04 and zoledronic acid/MG2+

Structural highlights

3n45 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.88Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FPPS_HUMAN Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3n45, resolution 1.88Å

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