3n1v: Difference between revisions

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OCA

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-{{Seed}}
-[[Image:3n1v.jpg|left|200px]]
-<!--
+==Human FPPS COMPLEX WITH FBS_01==
-The line below this paragraph, containing "STRUCTURE_3n1v", creates the "Structure Box" on the page.
+<StructureSection load='3n1v' size='340' side='right'caption='[[3n1v]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3n1v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N1V FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3N1:(5-CHLORO-3-METHYL-1-BENZOTHIOPHEN-2-YL)ACETIC+ACID'>3N1</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-{{STRUCTURE_3n1v|  PDB=3n1v  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n1v OCA], [https://pdbe.org/3n1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n1v RCSB], [https://www.ebi.ac.uk/pdbsum/3n1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n1v ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n1/3n1v_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n1v ConSurf].
+<div style="clear:both"></div>
-===Human FPPS COMPLEX WITH FBS_01===
+==See Also==
+*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-N1V is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1V OCA].
 [[Category: Homo sapiens]]
-[[Category: Rondeau, J M.]]
+[[Category: Large Structures]]
-[[Category: Bisphosphonate]]
+[[Category: Rondeau J-M]]
-[[Category: Cholesterol biosynthesis]]
-[[Category: Fragment-based screening]]
-[[Category: Isoprene biosynthesis]]
-[[Category: Transferase]]
-[[Category: Transferase-transferase inhibitor complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:46:37 2010''