3mjh: Difference between revisions

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{{STRUCTURE_3mjh|  PDB=3mjh  |  SCENE=  }}
===Crystal Structure of Human Rab5A in complex with the C2H2 Zinc Finger of EEA1===
{{ABSTRACT_PUBMED_20534488}}


==Function==
==Crystal Structure of Human Rab5A in complex with the C2H2 Zinc Finger of EEA1==
[[http://www.uniprot.org/uniprot/RAB5A_HUMAN RAB5A_HUMAN]] Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.<ref>PMID:14978216</ref> [[http://www.uniprot.org/uniprot/EEA1_HUMAN EEA1_HUMAN]] Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.  
<StructureSection load='3mjh' size='340' side='right'caption='[[3mjh]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3mjh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MJH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mjh OCA], [https://pdbe.org/3mjh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mjh RCSB], [https://www.ebi.ac.uk/pdbsum/3mjh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mjh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RAB5A_HUMAN RAB5A_HUMAN] Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.<ref>PMID:14978216</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mj/3mjh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mjh ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
[[3mjh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJH OCA].
*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:020534488</ref><references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Small monomeric GTPase]]
[[Category: Large Structures]]
[[Category: Eathiraj, S.]]
[[Category: Eathiraj S]]
[[Category: Lambright, D G.]]
[[Category: Lambright DG]]
[[Category: Mishra, A K.]]
[[Category: Mishra AK]]
[[Category: Beta beta alpha fold]]
[[Category: Beta hairpin]]
[[Category: Eea1]]
[[Category: Protein transport]]
[[Category: Protein-zinc finger complex]]
[[Category: Rab5a gtpase]]

Latest revision as of 13:25, 21 February 2024

Crystal Structure of Human Rab5A in complex with the C2H2 Zinc Finger of EEA1Crystal Structure of Human Rab5A in complex with the C2H2 Zinc Finger of EEA1

Structural highlights

3mjh is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.03Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RAB5A_HUMAN Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. Mol Biol Cell. 2004 May;15(5):2205-17. Epub 2004 Feb 20. PMID:14978216 doi:10.1091/mbc.E03-07-0493

3mjh, resolution 2.03Å

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