3mht: Difference between revisions

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-{{Seed}}
-[[Image:3mht.png|left|200px]]
-<!--
+==TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH UNMODIFIED DNA AND ADOHCY==
-The line below this paragraph, containing "STRUCTURE_3mht", creates the "Structure Box" on the page.
+<StructureSection load='3mht' size='340' side='right'caption='[[3mht]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3mht]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MHT FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-{{STRUCTURE_3mht|  PDB=3mht  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mht OCA], [https://pdbe.org/3mht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mht RCSB], [https://www.ebi.ac.uk/pdbsum/3mht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mht ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MTH1_HAEPH MTH1_HAEPH] This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mh/3mht_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mht ConSurf].
+<div style="clear:both"></div>
-===TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH UNMODIFIED DNA AND ADOHCY===
+==See Also==
+*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_8800212}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 8800212 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_8800212}}
-==About this Structure==
-MHT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MHT OCA].
-==Reference==
-Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes., O'Gara M, Klimasauskas S, Roberts RJ, Cheng X, J Mol Biol. 1996 Sep 6;261(5):634-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8800212 8800212]
 [[Category: Haemophilus haemolyticus]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Cheng, X.]]
+[[Category: Cheng X]]
-[[Category: Gara, M O.]]
+[[Category: Klimasauskas S]]
-[[Category: Klimasauskas, S.]]
+[[Category: O'Gara M]]
-[[Category: Roberts, R J.]]
+[[Category: Roberts RJ]]
-[[Category: Methyltransferase]]
-[[Category: Restriction system]]
-[[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 12:56:03 2008''