3mf0: Difference between revisions

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-[[Image:3mf0.png|left|200px]]
-{{STRUCTURE_3mf0|  PDB=3mf0  |  SCENE=  }}
+==Crystal structure of PDE5A GAF domain (89-518)==
+<StructureSection load='3mf0' size='340' side='right'caption='[[3mf0]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-===Crystal structure of PDE5A GAF domain (89-518)===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3mf0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MF0 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_20861010}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mf0 OCA], [https://pdbe.org/3mf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mf0 RCSB], [https://www.ebi.ac.uk/pdbsum/3mf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mf0 ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[3mf0]] is a 2 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MF0 OCA].
+== Function ==
+[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mf/3mf0_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mf0 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Phosphodiesterase|Phosphodiesterase]]
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:020861010</ref><references group="xtra"/>
-[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
 [[Category: Homo sapiens]]
-[[Category: Ke, H.]]
+[[Category: Large Structures]]
-[[Category: Robinson, H.]]
+[[Category: Ke H]]
-[[Category: Wang, H.]]
+[[Category: Robinson H]]
-[[Category: Cgmp signal]]
+[[Category: Wang H]]
-[[Category: Gaf]]
-[[Category: Hydrolase]]