3mdc: Difference between revisions

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OCA

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-{{Seed}}
-[[Image:3mdc.jpg|left|200px]]
-<!--
+==DNA polymerase lambda in complex with dFdCTP==
-The line below this paragraph, containing "STRUCTURE_3mdc", creates the "Structure Box" on the page.
+<StructureSection load='3mdc' size='340' side='right'caption='[[3mdc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3mdc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MDC FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.999&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTF:2-DEOXY-2,2-DIFLUOROCYTIDINE+5-(TETRAHYDROGEN+TRIPHOSPHATE)'>GTF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-{{STRUCTURE_3mdc|  PDB=3mdc  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdc OCA], [https://pdbe.org/3mdc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mdc RCSB], [https://www.ebi.ac.uk/pdbsum/3mdc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mdc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DPOLL_HUMAN DPOLL_HUMAN] Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.<ref>PMID:11457865</ref> <ref>PMID:15537631</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/3mdc_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mdc ConSurf].
+<div style="clear:both"></div>
-===DNA polymerase lambda in complex with dFdCTP===
+==See Also==
+*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_20348107}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 20348107 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_20348107}}
-==About this Structure==
-MDC is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDC OCA].
-==Reference==
-<ref group="xtra">PMID:20348107</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Chou, K M.]]
+[[Category: Large Structures]]
-[[Category: Garcia-Diaz, M.]]
+[[Category: Chou KM]]
-[[Category: Kunkel, T.]]
+[[Category: Garcia-Diaz M]]
-[[Category: Murray, M.]]
+[[Category: Kunkel T]]
-[[Category: Lyase]]
+[[Category: Murray M]]
-[[Category: Protein-dna complex]]
-[[Category: Transferase-dna complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 10:55:07 2010''