3m4e: Difference between revisions

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-[[Image:3m4e.png|left|200px]]
-{{STRUCTURE_3m4e|  PDB=3m4e  |  SCENE=  }}
+==Crystal structure of the M113N mutant of alpha-hemolysin bound to beta-cyclodextrin==
+<StructureSection load='3m4e' size='340' side='right'caption='[[3m4e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-===Crystal structure of the M113N mutant of alpha-hemolysin bound to beta-cyclodextrin===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3m4e]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M4E FirstGlance]. <br>
-{{ABSTRACT_PUBMED_20400691}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900012:beta-cyclodextrin'>PRD_900012</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m4e OCA], [https://pdbe.org/3m4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m4e RCSB], [https://www.ebi.ac.uk/pdbsum/3m4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m4e ProSAT]</span></td></tr>
-[[3m4e]] is a 7 chain structure of [[Hemolysin]] with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4E OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/3m4e_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m4e ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Hemolysin|Hemolysin]]
+*[[Hemolysin 3D structures|Hemolysin 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:020400691</ref><references group="xtra"/>
+[[Category: Large Structures]]
 [[Category: Staphylococcus aureus]]
-[[Category: Gouaux, E.]]
+[[Category: Gouaux E]]
-[[Category: Montoya, M.]]
+[[Category: Montoya M]]
-[[Category: Beta barrel]]
-[[Category: Cell invasion]]
-[[Category: Cytolysis]]
-[[Category: Cytolytic protein]]
-[[Category: Hemolysis]]
-[[Category: Secreted]]
-[[Category: Toxin]]