3m4e: Difference between revisions

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[[Image:3m4e.jpg|left|200px]]


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==Crystal structure of the M113N mutant of alpha-hemolysin bound to beta-cyclodextrin==
The line below this paragraph, containing "STRUCTURE_3m4e", creates the "Structure Box" on the page.
<StructureSection load='3m4e' size='340' side='right'caption='[[3m4e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3m4e]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M4E FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900012:beta-cyclodextrin'>PRD_900012</scene></td></tr>
{{STRUCTURE_3m4e| PDB=3m4e |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m4e OCA], [https://pdbe.org/3m4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m4e RCSB], [https://www.ebi.ac.uk/pdbsum/3m4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m4e ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/3m4e_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m4e ConSurf].
<div style="clear:both"></div>


===Crystal structure of the M113N mutant of alpha-hemolysin bound to beta-cyclodextrin===
==See Also==
 
*[[Hemolysin 3D structures|Hemolysin 3D structures]]
 
__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_20400691}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_20400691}}
 
==About this Structure==
3M4E is a 7 chains structure with sequences from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4E OCA].
 
==Reference==
<ref group="xtra">PMID:20400691</ref><references group="xtra"/>
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Gouaux, E.]]
[[Category: Gouaux E]]
[[Category: Montoya, M.]]
[[Category: Montoya M]]
[[Category: Beta barrel]]
[[Category: Cell invasion]]
[[Category: Cytolysis]]
[[Category: Cytolytic protein]]
[[Category: Hemolysis]]
[[Category: Secreted]]
[[Category: Toxin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May  5 11:54:56 2010''

Latest revision as of 13:23, 21 February 2024

Crystal structure of the M113N mutant of alpha-hemolysin bound to beta-cyclodextrinCrystal structure of the M113N mutant of alpha-hemolysin bound to beta-cyclodextrin

Structural highlights

3m4e is a 7 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HLA_STAAU Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3m4e, resolution 2.30Å

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