3m08: Difference between revisions

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OCA

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-[[Image:3m08.png|left|200px]]
-<!--
+==Wild Type Dihydrofolate Reductase from Staphylococcus aureus with inhibitor RAB1==
-The line below this paragraph, containing "STRUCTURE_3m08", creates the "Structure Box" on the page.
+<StructureSection load='3m08' size='340' side='right'caption='[[3m08]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3m08]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M08 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.014&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=RAR:5-(3,4-DIMETHOXY-5-{(1E)-3-OXO-3-[(1S)-1-PROPYLPHTHALAZIN-2(1H)-YL]PROP-1-EN-1-YL}BENZYL)PYRIMIDINE-2,4-DIAMINE'>RAR</scene></td></tr>
-{{STRUCTURE_3m08|  PDB=3m08  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m08 OCA], [https://pdbe.org/3m08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m08 RCSB], [https://www.ebi.ac.uk/pdbsum/3m08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m08 ProSAT]</span></td></tr>
+</table>
-===Wild Type Dihydrofolate Reductase from Staphylococcus aureus with inhibitor RAB1===
+== Function ==
+[https://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_20606069}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 20606069 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m0/3m08_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_20606069}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-[[3m08]] is a 1 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M08 OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m08 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Dihydrofolate reductase]]
+*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:20606069</ref><references group="xtra"/>
+[[Category: Large Structures]]
-[[Category: Dihydrofolate reductase]]
 [[Category: Staphylococcus aureus]]
-[[Category: Barrow, W W.]]
+[[Category: Barrow WW]]
-[[Category: Bourne, C R.]]
+[[Category: Bourne CR]]
-[[Category: Antibiotic resistance]]
-[[Category: Antimicrobial]]
-[[Category: Dhfr]]
-[[Category: Folate]]
-[[Category: Nadp]]
-[[Category: One-carbon metabolism]]
-[[Category: Oxidoreductases']]
-[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]