3lrv: Difference between revisions

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[[Image:3lrv.jpg|left|200px]]


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==The Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for its Function.==
The line below this paragraph, containing "STRUCTURE_3lrv", creates the "Structure Box" on the page.
<StructureSection load='3lrv' size='340' side='right'caption='[[3lrv]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3lrv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LRV FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3lrv| PDB=3lrv |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lrv OCA], [https://pdbe.org/3lrv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lrv RCSB], [https://www.ebi.ac.uk/pdbsum/3lrv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lrv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRP19_YEAST PRP19_YEAST] Involved in pre-mRNA splicing. Acts a central component of the NTC complex (or PRP19-associated complex) that associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. Involved in DNA repair.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/3lrv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lrv ConSurf].
<div style="clear:both"></div>


===The Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for its Function.===
==See Also==
 
*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
 
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_20462492}}
 
==About this Structure==
3LRV is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRV OCA].
 
==Reference==
<ref group="xtra">PMID:20462492</ref><references group="xtra"/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Chazin, W J.]]
[[Category: Chazin WJ]]
[[Category: Kooi, C W.Vander.]]
[[Category: Vander Kooi CW]]
[[Category: Dna damage]]
[[Category: Dna repair]]
[[Category: E3 ubiquitin ligase]]
[[Category: Mrna processing]]
[[Category: Mrna splicing]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Prp19]]
[[Category: Spliceosome]]
[[Category: Splicing]]
[[Category: Wd repeat]]
[[Category: Wd40]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 26 08:33:21 2010''

Latest revision as of 13:22, 21 February 2024

The Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for its Function.The Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for its Function.

Structural highlights

3lrv is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PRP19_YEAST Involved in pre-mRNA splicing. Acts a central component of the NTC complex (or PRP19-associated complex) that associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. Involved in DNA repair.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3lrv, resolution 2.60Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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