3lnx: Difference between revisions

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[[Image:3lnx.png|left|200px]]


{{STRUCTURE_3lnx|  PDB=3lnx  |  SCENE=  }}
==Second PDZ domain from human PTP1E==
 
<StructureSection load='3lnx' size='340' side='right'caption='[[3lnx]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
===Second PDZ domain from human PTP1E===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3lnx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LNX FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.642&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
[[3lnx]] is a 6 chain structure of [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNX OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lnx OCA], [https://pdbe.org/3lnx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lnx RCSB], [https://www.ebi.ac.uk/pdbsum/3lnx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lnx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTN13_HUMAN PTN13_HUMAN] Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.<ref>PMID:15611135</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ln/3lnx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lnx ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Tyrosine phosphatase|Tyrosine phosphatase]]
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
[[Category: Large Structures]]
[[Category: Chang, A.]]
[[Category: Chang A]]
[[Category: Ke, H.]]
[[Category: Ke H]]
[[Category: Lee, A L.]]
[[Category: Lee AL]]
[[Category: Phillips, G N.]]
[[Category: Phillips Jr GN]]
[[Category: Zhang, J.]]
[[Category: Zhang J]]
[[Category: Center for eukaryotic structural genomic]]
[[Category: Cesg]]
[[Category: Cytoskeleton]]
[[Category: Pdz2]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Signaling protein]]
[[Category: Structural genomic]]

Latest revision as of 13:21, 21 February 2024

Second PDZ domain from human PTP1ESecond PDZ domain from human PTP1E

Structural highlights

3lnx is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.642Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PTN13_HUMAN Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Villa F, Deak M, Bloomberg GB, Alessi DR, van Aalten DM. Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket. J Biol Chem. 2005 Mar 4;280(9):8180-7. Epub 2004 Dec 20. PMID:15611135 doi:10.1074/jbc.M412211200

3lnx, resolution 1.64Å

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