3lim: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:3lim.png|left|200px]]
-<!--
+==Crystal structure of the pore forming toxin frac from sea anemone actinia fragacea==
-The line below this paragraph, containing "STRUCTURE_3lim", creates the "Structure Box" on the page.
+<StructureSection load='3lim' size='340' side='right'caption='[[3lim]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3lim]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinia_fragacea Actinia fragacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LIM FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>
-{{STRUCTURE_3lim|  PDB=3lim  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lim OCA], [https://pdbe.org/3lim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lim RCSB], [https://www.ebi.ac.uk/pdbsum/3lim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lim ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ACTPC_ACTFR ACTPC_ACTFR] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.<ref>PMID:19563820</ref>
-===Crystal structure of the pore forming toxin frac from sea anemone actinia fragacea===
+==See Also==
+*[[Cytolysin 3D structures|Cytolysin 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_21300287}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 21300287 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_21300287}}
-==About this Structure==
-[[3lim]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinia_fragacea Actinia fragacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LIM OCA].
-==Reference==
-<ref group="xtra">PMID:021300287</ref><references group="xtra"/>
 [[Category: Actinia fragacea]]
-[[Category: Bellomio, A.]]
+[[Category: Large Structures]]
-[[Category: Gonzalez-Manas, J M.]]
+[[Category: Bellomio A]]
-[[Category: Guerin, D M.A.]]
+[[Category: Gonzalez-Manas JM]]
-[[Category: Mechaly, A E.]]
+[[Category: Guerin DMA]]
-[[Category: Morante, K.]]
+[[Category: Mechaly AE]]
-[[Category: Actinoporin]]
+[[Category: Morante K]]
-[[Category: Pore forming toxin]]
-[[Category: Toxin]]