3kpd: Difference between revisions

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-{{Seed}}
-[[Image:3kpd.jpg|left|200px]]
-<!--
+==Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine.==
-The line below this paragraph, containing "STRUCTURE_3kpd", creates the "Structure Box" on the page.
+<StructureSection load='3kpd' size='340' side='right'caption='[[3kpd]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3kpd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KPD FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.91&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-{{STRUCTURE_3kpd|  PDB=3kpd  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kpd OCA], [https://pdbe.org/3kpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kpd RCSB], [https://www.ebi.ac.uk/pdbsum/3kpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kpd ProSAT]</span></td></tr>
+</table>
-===Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine.===
+== Function ==
+[https://www.uniprot.org/uniprot/ASST_METJA ASST_METJA] Required for O-acetylhomoserine sulfhydrylase (OAHS)-independent homocysteine (Hcy) biosynthesis. Together with MJ0099, catalyzes the condensation of sulfide with aspartate semialdehyde to generate homocysteine. Likely functions through persulfide intermediate.[UniProtKB:Q8TPT4]
+== Evolutionary Conservation ==
-==About this Structure==
+[[Image:Consurf_key_small.gif|200px|right]]
-KPD is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPD OCA].
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/3kpd_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kpd ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Methanocaldococcus jannaschii]]
-[[Category: Arribas, E Astigarraga.]]
+[[Category: Arribas EA]]
-[[Category: Encinar, J A.]]
+[[Category: Encinar JA]]
-[[Category: Fernandez, J A.]]
+[[Category: Fernandez JA]]
-[[Category: Garcia, I Gomez.]]
+[[Category: Garcia IG]]
-[[Category: Kortazar, D.]]
+[[Category: Kortazar D]]
-[[Category: Lucas, M.]]
+[[Category: Lucas M]]
-[[Category: Martinez-Chantar, M L.]]
+[[Category: Martinez-Chantar ML]]
-[[Category: Martinez-Cruz, L A.]]
+[[Category: Martinez-Cruz LA]]
-[[Category: Mato, J M.]]
+[[Category: Mato JM]]
-[[Category: Oyenarte, I.]]
+[[Category: Oyenarte I]]
-[[Category: Cbs domain]]
-[[Category: Conformational change]]
-[[Category: S-adenosylmethionine]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 14:41:25 2010''