3kov: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:3kov.jpg|left|200px]]
-<!--
+==Structure of MEF2A bound to DNA reveals a completely folded MADS-box/MEF2 domain that recognizes DNA and recruits transcription co-factors==
-The line below this paragraph, containing "STRUCTURE_3kov", creates the "Structure Box" on the page.
+<StructureSection load='3kov' size='340' side='right'caption='[[3kov]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3kov]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KOV FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kov OCA], [https://pdbe.org/3kov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kov RCSB], [https://www.ebi.ac.uk/pdbsum/3kov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kov ProSAT]</span></td></tr>
-{{STRUCTURE_3kov|  PDB=3kov  |  SCENE=  }}
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/MEF2A_HUMAN MEF2A_HUMAN] Defects in MEF2A are a cause of coronary artery disease, autosomal dominant, type 1 (ADCAD1) [MIM:[https://omim.org/entry/608320 608320]. A common heart disease characterized by reduced or absent blood flow in one or more of the arteries that encircle and supply the heart. Its most important complication is acute myocardial infarction.
+== Function ==
+[https://www.uniprot.org/uniprot/MEF2A_HUMAN MEF2A_HUMAN] Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation.<ref>PMID:9858528</ref> <ref>PMID:11904443</ref> <ref>PMID:12691662</ref> <ref>PMID:15834131</ref> <ref>PMID:16563226</ref> <ref>PMID:16371476</ref> <ref>PMID:16484498</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/3kov_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kov ConSurf].
+<div style="clear:both"></div>
-===Structure of MEF2A bound to DNA reveals a completely folded MADS-box/MEF2 domain that recognizes DNA and recruits transcription co-factors===
+==See Also==
+*[[Myocyte enhancer factor 2|Myocyte enhancer factor 2]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_20132824}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 20132824 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_20132824}}
-==About this Structure==
-KOV is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KOV OCA].
-==Reference==
-<ref group="xtra">PMID:20132824</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Chen, L.]]
+[[Category: Large Structures]]
-[[Category: Dey, R.]]
+[[Category: Chen L]]
-[[Category: Han, A.]]
+[[Category: Dey R]]
-[[Category: Jayathilaka, N.]]
+[[Category: Han A]]
-[[Category: Philips, M.]]
+[[Category: Jayathilaka N]]
-[[Category: Wu, Y.]]
+[[Category: Philips M]]
-[[Category: Ye, J.]]
+[[Category: Wu Y]]
-[[Category: Acetylation]]
+[[Category: Ye J]]
-[[Category: Activator]]
-[[Category: Alternative splicing]]
-[[Category: Apoptosis]]
-[[Category: Developmental protein]]
-[[Category: Differentiation]]
-[[Category: Disease mutation]]
-[[Category: Dna-binding]]
-[[Category: Isopeptide bond]]
-[[Category: Mads-box/mef2 domain]]
-[[Category: Neurogenesis]]
-[[Category: Nucleus]]
-[[Category: Phosphoprotein]]
-[[Category: Protein-dna complex]]
-[[Category: Protein-protein docking]]
-[[Category: Transcription]]
-[[Category: Transcription co-factor]]
-[[Category: Transcription regulation]]
-[[Category: Transcription-dna complex]]
-[[Category: Ubl conjugation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 10:33:52 2010''