3kfc: Difference between revisions

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[[Image:3kfc.jpg|left|200px]]


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==Complex Structure of LXR with an agonist==
The line below this paragraph, containing "STRUCTURE_3kfc", creates the "Structure Box" on the page.
<StructureSection load='3kfc' size='340' side='right'caption='[[3kfc]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3kfc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KFC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=61X:4-{3-[3-(METHYLSULFONYL)PHENOXY]PHENYL}-8-(TRIFLUOROMETHYL)QUINOLINE'>61X</scene></td></tr>
{{STRUCTURE_3kfc| PDB=3kfc |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kfc OCA], [https://pdbe.org/3kfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kfc RCSB], [https://www.ebi.ac.uk/pdbsum/3kfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kfc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kf/3kfc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kfc ConSurf].
<div style="clear:both"></div>


===Complex Structure of LXR with an agonist===
==See Also==
 
*[[Liver X receptor|Liver X receptor]]
 
__TOC__
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{{ABSTRACT_PUBMED_19932617}}
 
==About this Structure==
3KFC is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFC OCA].
 
==Reference==
<ref group="xtra">PMID:19932617</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bernotas, R C.]]
[[Category: Large Structures]]
[[Category: Olland, A.]]
[[Category: Bernotas RC]]
[[Category: Unwalla, R.]]
[[Category: Olland A]]
[[Category: Dna-binding]]
[[Category: Unwalla R]]
[[Category: Liver x receptor]]
[[Category: Lxr]]
[[Category: Lxr agonist]]
[[Category: Lxr ligand]]
[[Category: Metal-binding]]
[[Category: Nuclear receptor]]
[[Category: Nucleus]]
[[Category: Polymorphism]]
[[Category: Receptor]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec  9 15:06:15 2009''

Latest revision as of 13:16, 21 February 2024

Complex Structure of LXR with an agonistComplex Structure of LXR with an agonist

Structural highlights

3kfc is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NR1H2_HUMAN Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3kfc, resolution 2.40Å

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