3kb3: Difference between revisions

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-{{STRUCTURE_3kb3|  PDB=3kb3  |  SCENE=  }}
-===Crystal structure of abscisic acid-bound PYL2 in complex with HAB1===
-{{ABSTRACT_PUBMED_019898420}}
-==Function==
+==Crystal structure of abscisic acid-bound PYL2 in complex with HAB1==
-[[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref>
+<StructureSection load='3kb3' size='340' side='right'caption='[[3kb3]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3kb3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KB3 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A8S:(2Z,4E)-5-[(1S)-1-HYDROXY-2,6,6-TRIMETHYL-4-OXOCYCLOHEX-2-EN-1-YL]-3-METHYLPENTA-2,4-DIENOIC+ACID'>A8S</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kb3 OCA], [https://pdbe.org/3kb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kb3 RCSB], [https://www.ebi.ac.uk/pdbsum/3kb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kb3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/3kb3_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kb3 ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-[[3kb3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KB3 OCA].
+*[[Abscisic acid receptor 3D structures|Abscisic acid receptor 3D structures]]
+*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
-==Reference==
+== References ==
-<references group="xtra"/><references/>
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Arabidopsis thaliana]]
-[[Category: Phosphoprotein phosphatase]]
+[[Category: Large Structures]]
-[[Category: Kovach, A.]]
+[[Category: Kovach A]]
-[[Category: Li, J.]]
+[[Category: Li J]]
-[[Category: Melcher, K.]]
+[[Category: Melcher K]]
-[[Category: Ng, L M.]]
+[[Category: Ng L-M]]
-[[Category: Soon, F F.]]
+[[Category: Soon F-F]]
-[[Category: Suino-Powell, K M.]]
+[[Category: Suino-Powell KM]]
-[[Category: Xu, H E.]]
+[[Category: Xu HE]]
-[[Category: Xu, Y.]]
+[[Category: Xu Y]]
-[[Category: Zhou, X E.]]
+[[Category: Zhou XE]]
-[[Category: Abscisic acid signaling]]
-[[Category: Hab1]]
-[[Category: Phytohormone receptor]]
-[[Category: Pyl2]]
-[[Category: Pyr/pyl/rcar]]
-[[Category: Signaling protein]]
-[[Category: Type 2c protein phosphatase]]