3kb3: Difference between revisions

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[[Image:3kb3.jpg|left|200px]]


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==Crystal structure of abscisic acid-bound PYL2 in complex with HAB1==
The line below this paragraph, containing "STRUCTURE_3kb3", creates the "Structure Box" on the page.
<StructureSection load='3kb3' size='340' side='right'caption='[[3kb3]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3kb3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KB3 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A8S:(2Z,4E)-5-[(1S)-1-HYDROXY-2,6,6-TRIMETHYL-4-OXOCYCLOHEX-2-EN-1-YL]-3-METHYLPENTA-2,4-DIENOIC+ACID'>A8S</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_3kb3| PDB=3kb3 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kb3 OCA], [https://pdbe.org/3kb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kb3 RCSB], [https://www.ebi.ac.uk/pdbsum/3kb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kb3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/3kb3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kb3 ConSurf].
<div style="clear:both"></div>


===Crystal structure of abscisic acid-bound PYL2 in complex with HAB1===
==See Also==
 
*[[Abscisic acid receptor 3D structures|Abscisic acid receptor 3D structures]]
 
*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
==About this Structure==
== References ==
3KB3 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KB3 OCA].
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Large Structures]]
[[Category: Kovach, A.]]
[[Category: Kovach A]]
[[Category: Li, J.]]
[[Category: Li J]]
[[Category: Melcher, K.]]
[[Category: Melcher K]]
[[Category: Ng, L M.]]
[[Category: Ng L-M]]
[[Category: Soon, F F.]]
[[Category: Soon F-F]]
[[Category: Suino-Powell, K M.]]
[[Category: Suino-Powell KM]]
[[Category: Xu, H E.]]
[[Category: Xu HE]]
[[Category: Xu, Y.]]
[[Category: Xu Y]]
[[Category: Zhou, X E.]]
[[Category: Zhou XE]]
[[Category: Abscisic acid signaling]]
[[Category: Hab1]]
[[Category: Phytohormone receptor]]
[[Category: Pyl2]]
[[Category: Pyr/pyl/rcar]]
[[Category: Type 2c protein phosphatase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec  9 16:05:58 2009''

Latest revision as of 13:16, 21 February 2024

Crystal structure of abscisic acid-bound PYL2 in complex with HAB1Crystal structure of abscisic acid-bound PYL2 in complex with HAB1

Structural highlights

3kb3 is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.95Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PYL2_ARATH Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Li J, Peterson FC, Jensen DR, Yong EL, Volkman BF, Cutler SR, Zhu JK, Xu HE. A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature. 2009 Dec 3;462(7273):602-8. PMID:19898420 doi:10.1038/nature08613
  2. ↑ Yin P, Fan H, Hao Q, Yuan X, Wu D, Pang Y, Yan C, Li W, Wang J, Yan N. Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol. 2009 Dec;16(12):1230-6. Epub 2009 Nov 5. PMID:19893533 doi:10.1038/nsmb.1730

3kb3, resolution 1.95Å

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