3k4o: Difference between revisions

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{{STRUCTURE_3k4o|  PDB=3k4o  |  SCENE=  }}
===Crystal Structure of Isopentenyl Phosphate Kinase from Methanocaldococcus jannaschii===
{{ABSTRACT_PUBMED_20392112}}


==About this Structure==
==Crystal Structure of Isopentenyl Phosphate Kinase from Methanocaldococcus jannaschii==
[[3k4o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K4O OCA].  
<StructureSection load='3k4o' size='340' side='right'caption='[[3k4o]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
 
== Structural highlights ==
==Reference==
<table><tr><td colspan='2'>[[3k4o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K4O FirstGlance]. <br>
<ref group="xtra">PMID:020392112</ref><references group="xtra"/><references/>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
[[Category: Methanocaldococcus jannaschii]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Dellas, N.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k4o OCA], [https://pdbe.org/3k4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k4o RCSB], [https://www.ebi.ac.uk/pdbsum/3k4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k4o ProSAT]</span></td></tr>
[[Category: Noel, J P.]]
</table>
[[Category: Archaea]]
== Function ==
[[Category: Atp-binding]]
[https://www.uniprot.org/uniprot/IPK_METJA IPK_METJA] Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. Has no activity with farnesyl phosphate.<ref>PMID:16621811</ref> <ref>PMID:20392112</ref>
[[Category: Isopentenyl diphosphate]]
== Evolutionary Conservation ==
[[Category: Isopentenyl monophosphate]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Isoprenoid biosynthesis]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k4/3k4o_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k4o ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Mevalonate pathway]]
[[Category: Dellas N]]
[[Category: Small molecule kinase]]
[[Category: Noel JP]]
[[Category: Transferase]]

Latest revision as of 13:15, 21 February 2024

Crystal Structure of Isopentenyl Phosphate Kinase from Methanocaldococcus jannaschiiCrystal Structure of Isopentenyl Phosphate Kinase from Methanocaldococcus jannaschii

Structural highlights

3k4o is a 2 chain structure with sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.05Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IPK_METJA Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. Has no activity with farnesyl phosphate.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Grochowski LL, Xu H, White RH. Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. J Bacteriol. 2006 May;188(9):3192-8. PMID:16621811 doi:http://dx.doi.org/10.1128/JB.188.9.3192-3198.2006
  2. ↑ Dellas N, Noel JP. Mutation of Archaeal Isopentenyl Phosphate Kinase Highlights Mechanism and Guides Phosphorylation of Additional Isoprenoid Monophosphates. ACS Chem Biol. 2010 Apr 14. PMID:20392112 doi:10.1021/cb1000313

3k4o, resolution 2.05Å

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