3jr6: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(5 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:3jr6.png|left|200px]]


{{STRUCTURE_3jr6|  PDB=3jr6  |  SCENE=  }}
==Sequential reorganization of beta-sheet topology by insertion of a single strand==
 
<StructureSection load='3jr6' size='340' side='right'caption='[[3jr6]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
===Sequential reorganization of beta-sheet topology by insertion of a single strand===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3jr6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2b7w 2b7w]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JR6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JR6 FirstGlance]. <br>
{{ABSTRACT_PUBMED_16597830}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jr6 OCA], [https://pdbe.org/3jr6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jr6 RCSB], [https://www.ebi.ac.uk/pdbsum/3jr6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jr6 ProSAT]</span></td></tr>
[[3jr6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2b7w 2b7w]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JR6 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/3jr6_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jr6 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Hen Egg-White (HEW) Lysozyme|Hen Egg-White (HEW) Lysozyme]]
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:016597830</ref><ref group="xtra">PMID:012869697</ref><ref group="xtra">PMID:010339544</ref><references group="xtra"/>
__TOC__
[[Category: Enterobacteria phage t4]]
</StructureSection>
[[Category: Lysozyme]]
[[Category: Escherichia virus T4]]
[[Category: Baas, W A.]]
[[Category: Large Structures]]
[[Category: Matthews, B W.]]
[[Category: Baas WA]]
[[Category: Sagermann, M.]]
[[Category: Matthews BW]]
[[Category: Antimicrobial]]
[[Category: Sagermann M]]
[[Category: Bacteriolytic enzyme]]
[[Category: Beta-sheet]]
[[Category: Glycosidase]]
[[Category: Hydrolase]]
[[Category: Protein design]]
[[Category: Sequence duplication]]
[[Category: Tandem repeat]]

Latest revision as of 13:13, 21 February 2024

Sequential reorganization of beta-sheet topology by insertion of a single strandSequential reorganization of beta-sheet topology by insertion of a single strand

Structural highlights

3jr6 is a 4 chain structure with sequence from Escherichia virus T4. This structure supersedes the now removed PDB entry 2b7w. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ENLYS_BPT4 Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Moussa SH, Kuznetsov V, Tran TA, Sacchettini JC, Young R. Protein determinants of phage T4 lysis inhibition. Protein Sci. 2012 Apr;21(4):571-82. doi: 10.1002/pro.2042. Epub 2012 Mar 2. PMID:22389108 doi:http://dx.doi.org/10.1002/pro.2042

3jr6, resolution 3.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=3jr6&oldid=4065910"