3iu2: Difference between revisions

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[[Image:3iu2.png|left|200px]]


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==Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096==
The line below this paragraph, containing "STRUCTURE_3iu2", creates the "Structure Box" on the page.
<StructureSection load='3iu2' size='340' side='right'caption='[[3iu2]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3iu2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IU2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=096:(2R)-2-{4-HYDROXY-5-METHOXY-2-[3-(4-METHYLPIPERAZIN-1-YL)PROPYL]PHENYL}-3-PYRIDIN-3-YL-1,3-THIAZOLIDIN-4-ONE'>096</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr>
{{STRUCTURE_3iu2|  PDB=3iu2  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iu2 OCA], [https://pdbe.org/3iu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iu2 RCSB], [https://www.ebi.ac.uk/pdbsum/3iu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iu2 ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096===
== Function ==
 
[https://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
[[3iu2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU2 OCA].  
Check<jmol>
[[Category: Glycylpeptide N-tetradecanoyltransferase]]
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iu/3iu2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iu2 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bochkarev, A.]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C.]]
[[Category: Bochkarev A]]
[[Category: Brand, S Y.]]
[[Category: Bountra C]]
[[Category: Cossar, D.]]
[[Category: Brand SY]]
[[Category: Edwards, A M.]]
[[Category: Cossar D]]
[[Category: Ferguson, M A.J.]]
[[Category: Edwards AM]]
[[Category: Frearson, J A.]]
[[Category: Ferguson MAJ]]
[[Category: Hui, R.]]
[[Category: Frearson JA]]
[[Category: Hutchinson, A.]]
[[Category: Hui R]]
[[Category: Kania, A.]]
[[Category: Hutchinson A]]
[[Category: Kozieradzki, I.]]
[[Category: Kania A]]
[[Category: Lin, Y H.]]
[[Category: Kozieradzki I]]
[[Category: Qiu, W.]]
[[Category: Lin Y-H]]
[[Category: Ravichandran, M.]]
[[Category: Qiu W]]
[[Category: Robinson, D A.]]
[[Category: Ravichandran M]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Robinson DA]]
[[Category: Schapira, M.]]
[[Category: Schapira M]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Wernimont, A.]]
[[Category: Wernimont A]]
[[Category: Wyatt, P G.]]
[[Category: Wyatt PG]]
[[Category: Acyltransfera]]
[[Category: Acyltransferase]]
[[Category: N-myristoyltransferase]]
[[Category: Nmt1]]
[[Category: Phosphoprotein]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Transferase]]

Latest revision as of 13:06, 21 February 2024

Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096

Structural highlights

3iu2 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.73Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NMT1_HUMAN Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

3iu2, resolution 1.73Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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