3itm: Difference between revisions

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[[Image:3itm.jpg|left|200px]]


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==Catalytic domain of hPDE2A==
The line below this paragraph, containing "STRUCTURE_3itm", creates the "Structure Box" on the page.
<StructureSection load='3itm' size='340' side='right'caption='[[3itm]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3itm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ITM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ITM FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3itm| PDB=3itm |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3itm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3itm OCA], [https://pdbe.org/3itm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3itm RCSB], [https://www.ebi.ac.uk/pdbsum/3itm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3itm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE2A_HUMAN PDE2A_HUMAN] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.<ref>PMID:15938621</ref> <ref>PMID:19828435</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/it/3itm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3itm ConSurf].
<div style="clear:both"></div>


===Catalytic domain of hPDE2A===
==See Also==
 
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 
== References ==
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</StructureSection>
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{{ABSTRACT_PUBMED_19828435}}
 
==About this Structure==
3ITM is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ITM OCA].
 
==Reference==
<ref group="xtra">PMID:19828435</ref><references group="xtra"/>
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Pandit, J.]]
[[Category: Large Structures]]
[[Category: All-alpha helical]]
[[Category: Pandit J]]
[[Category: Alternative splicing]]
[[Category: Cgmp]]
[[Category: Hydrolase]]
[[Category: Membrane]]
[[Category: Polymorphism]]
[[Category: Zn-binding]]
 
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