3ifk: Difference between revisions

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[[Image:3ifk.png|left|200px]]


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==Crystal Structure Of Calcium-Saturated Calmodulin N-terminal Domain Fragment, Residues 1-90==
The line below this paragraph, containing "STRUCTURE_3ifk", creates the "Structure Box" on the page.
<StructureSection load='3ifk' size='340' side='right'caption='[[3ifk]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ifk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IFK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
{{STRUCTURE_3ifk|  PDB=3ifk  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ifk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ifk OCA], [https://pdbe.org/3ifk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ifk RCSB], [https://www.ebi.ac.uk/pdbsum/3ifk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ifk ProSAT]</span></td></tr>
 
</table>
===Crystal Structure Of Calcium-Saturated Calmodulin N-terminal Domain Fragment, Residues 1-90===
== Function ==
 
[https://www.uniprot.org/uniprot/CALM1_RAT CALM1_RAT] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2.[UniProtKB:P62158]
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/3ifk_consurf.spt"</scriptWhenChecked>
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
[[3ifk]] is a 2 chain structure of [[Calmodulin]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IFK OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ifk ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Calmodulin]]
*[[Calmodulin 3D structures|Calmodulin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:021609874</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Newman, R A.]]
[[Category: Newman RA]]
[[Category: Shea, M A.]]
[[Category: Shea MA]]
[[Category: Witt, T J.]]
[[Category: Witt TJ]]
[[Category: Calmodulin]]
[[Category: Ef hand motif]]
[[Category: Isopeptide bond]]
[[Category: Metal binding protein]]
[[Category: Methylation]]
[[Category: N-domain]]
[[Category: N-terminal domain]]
[[Category: Phosphoprotein]]
[[Category: Phosphorylation]]
[[Category: Residues 1-90]]

Latest revision as of 13:05, 21 February 2024

Crystal Structure Of Calcium-Saturated Calmodulin N-terminal Domain Fragment, Residues 1-90Crystal Structure Of Calcium-Saturated Calmodulin N-terminal Domain Fragment, Residues 1-90

Structural highlights

3ifk is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.03Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CALM1_RAT Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2.[UniProtKB:P62158]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3ifk, resolution 2.03Å

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OCA
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