3ia4: Difference between revisions

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[[Image:3ia4.png|left|200px]]


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==Moritella profunda dihydrofolate reductase (DHFR) in complex with NADPH and methotrexate (MTX)==
The line below this paragraph, containing "STRUCTURE_3ia4", creates the "Structure Box" on the page.
<StructureSection load='3ia4' size='340' side='right'caption='[[3ia4]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ia4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IA4 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
{{STRUCTURE_3ia4| PDB=3ia4 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ia4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ia4 OCA], [https://pdbe.org/3ia4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ia4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ia4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ia4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q70YQ6_MORPR Q70YQ6_MORPR] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/3ia4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ia4 ConSurf].
<div style="clear:both"></div>


===Moritella profunda dihydrofolate reductase (DHFR) in complex with NADPH and methotrexate (MTX)===
==See Also==
 
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_19681091}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 19681091 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19681091}}
 
==About this Structure==
3IA4 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IA4 OCA].
 
==Reference==
<ref group="xtra">PMID:19681091</ref><references group="xtra"/>
[[Category: Dihydrofolate reductase]]
[[Category: Moritella profunda]]
[[Category: Moritella profunda]]
[[Category: Levy, C.]]
[[Category: Levy C]]
[[Category: Dhfr dihydrofolate reductase]]
[[Category: Methotrexate]]
[[Category: Nadph]]
[[Category: Oxidoreductase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep  3 15:58:38 2009''

Latest revision as of 13:04, 21 February 2024

Moritella profunda dihydrofolate reductase (DHFR) in complex with NADPH and methotrexate (MTX)Moritella profunda dihydrofolate reductase (DHFR) in complex with NADPH and methotrexate (MTX)

Structural highlights

3ia4 is a 4 chain structure with sequence from Moritella profunda. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q70YQ6_MORPR Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3ia4, resolution 1.70Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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