3ia5: Difference between revisions

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-[[Image:3ia5.png|left|200px]]
-{{STRUCTURE_3ia5|  PDB=3ia5  |  SCENE=  }}
+==Moritella profunda dihydrofolate reductase (DHFR)==
+<StructureSection load='3ia5' size='340' side='right'caption='[[3ia5]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-===Moritella profunda dihydrofolate reductase (DHFR)===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3ia5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IA5 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_19681091}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ia5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ia5 OCA], [https://pdbe.org/3ia5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ia5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ia5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ia5 ProSAT]</span></td></tr>
-[[3ia5]] is a 2 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IA5 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q70YQ6_MORPR Q70YQ6_MORPR] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/3ia5_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ia5 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Dihydrofolate reductase|Dihydrofolate reductase]]
+*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:019681091</ref><references group="xtra"/>
+[[Category: Large Structures]]
-[[Category: Dihydrofolate reductase]]
 [[Category: Moritella profunda]]
-[[Category: Allemann, R K.]]
+[[Category: Allemann RK]]
-[[Category: Evans, R M.]]
+[[Category: Evans RM]]
-[[Category: Hay, S.]]
+[[Category: Hay S]]
-[[Category: Levy, C.]]
+[[Category: Levy C]]
-[[Category: Leys, D.]]
+[[Category: Leys D]]
-[[Category: Loveridge, E J.]]
+[[Category: Loveridge EJ]]
-[[Category: Scrutton, N S.]]
+[[Category: Scrutton NS]]
-[[Category: Wang, X.]]
+[[Category: Wang X]]
-[[Category: Dhfr dihydrofolate reductase]]
-[[Category: Oxidoreductase]]