3i4h: Difference between revisions

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-{{Seed}}
-[[Image:3i4h.png|left|200px]]
-<!--
+==Crystal structure of Cas6 in Pyrococcus furiosus==
-The line below this paragraph, containing "STRUCTURE_3i4h", creates the "Structure Box" on the page.
+<StructureSection load='3i4h' size='340' side='right'caption='[[3i4h]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3i4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I4H FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i4h OCA], [https://pdbe.org/3i4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i4h RCSB], [https://www.ebi.ac.uk/pdbsum/3i4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i4h ProSAT]</span></td></tr>
-{{STRUCTURE_3i4h|  PDB=3i4h  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CAS6_PYRFU CAS6_PYRFU] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), also called psiRNA (prokaryotic silencing) in this organism. This protein processes pre-crRNA into individual crRNA units, with an 8-nt 5'-repeat DNA tag that may help other proteins recognize the crRNA. Further processing occurs at their 3' termini in this organism. Generates a 5'-hydroxy and 2',3'-cyclic phosphodiester.<ref>PMID:19141480</ref> <ref>PMID:20884784</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i4/3i4h_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i4h ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of Cas6 in Pyrococcus furiosus===
+==See Also==
+*[[CRISPR subtype III-B (Cmr complex)|CRISPR subtype III-B (Cmr complex)]]
+*[[CRISPR-Cas|CRISPR-Cas]]
-<!--
+*[[Endonuclease 3D structures|Endonuclease 3D structures]]
-The line below this paragraph, {{ABSTRACT_PUBMED_19141480}}, adds the Publication Abstract to the page
+== References ==
-(as it appears on PubMed at http://www.pubmed.gov), where 19141480 is the PubMed ID number.
+<references/>
--->
+__TOC__
-{{ABSTRACT_PUBMED_19141480}}
+</StructureSection>
+[[Category: Large Structures]]
-==About this Structure==
-I4H is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4H OCA].
-==Reference==
-<ref group="xtra">PMID:19141480</ref><references group="xtra"/>
 [[Category: Pyrococcus furiosus]]
-[[Category: Carte, J.]]
+[[Category: Carte J]]
-[[Category: Li, H.]]
+[[Category: Li H]]
-[[Category: Terns, M P.]]
+[[Category: Terns MP]]
-[[Category: Terns, R M.]]
+[[Category: Terns RM]]
-[[Category: Wang, R.]]
+[[Category: Wang R]]
-[[Category: Endoribonuclease]]
-[[Category: Hydrolase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:14:50 2010''